The banknote-printing wastewater has highly concentrated organic matter with high colourity. Through investigation and analysis, hydrolytic-acidification and aerobic process, adding chemical sedimentation technology has been chosen. The scale of this treatment is 1 100 m³/d, and the average influent COD_Cr is 330 mg/L, the maximum is 1 600 mg/L. After the treatment, the average effluent COD_Cr is 21 mg/L, the maximum is 74 mg/L, and the other results have also reached the requirement. It is shown that this process is more suitable for the banknate-printing wastewater treatment and the outlet water meets the national discharge standard and design requirement.