The research demonstrates that it is feasible to treat antibiotic production wastewater with the following process: hydrolysis acidification - two stage biological contact oxidation process denitrification - phosphate and chroma removal with modified fly ash - sewage sludge conditioning with fly ash. In this paper, a new method is put forward to treat high concentration of antibiotic production wastewater, and this process would be the dominant process in treating this kind of wastewater.