A novel kind of polymer bio-carrier is applied to treat highly concentrated antibiotic wastewater by flui-dized-bed bioreactor.The experimental results show that this kind of bio-carriers has good property for microorganism habitat on it and quick starting up.The biomass attached on the carries is up to 4 136mg/L in one month; the COD removal efficiency of above 85% could be achieved when the bio-carriers apparent volume is 50% of the reactor volume and the influent COD volume loading is under 2.5 kg/(m³d).The average BOD₅ removal efficiency is up to 89.21% at stable operation stage,which is simultaneous with the COD removal rate.The dynamic change of suspended sludge SS and total biomass MLSS during the whole operation period show that SS and MLSS are basically constant at stable stage.SS would decrease while MLSS increase when the reactor system suffers from high loading impact.What′s more,the microorganism activity is greatly enhanced,biofilm growth entered adaption step,which indicates that the ability of fluidized-bed bioreactor of resistance to high loading impact is strengthened.