超声技术在降解药物活性化合物中的应用

doi:10.11894/1005-829x.2018.38(9).012

摘要/Abstract

摘要： 超声降解技术是一种新型的氧化技术，该技术利用超声波的空化作用、声致自由基氧化和超临界水氧化强化污染物降解反应的进行，通过反应产生的强氧化性自由基——羟基自由基（·OH）对药物活性化合物进行羟基化、脱卤、去甲基化、脱羧、脱氨等作用，将其氧化成无毒害物质。从超声降解药物活性化合物的作用机理、主要影响因素及超声与其他水处理技术联用方面进行综合性阐述，并指出超声技术在今后大规模化应用中需解决的问题和发展方向。

关键词: 超声波, 超声降解, 药物活性化合物

Abstract: Ultrasonic degradation technology is a new type of oxidation technology,which uses ultrasonic wave cavitation effect,acoustic free radical oxidation,and supercritical water oxidation,for strengthening the implementation of the degradation reaction of pollutants. The strong oxidizing free radicals-hydroxyl radicals(·OH) produced by the reaction have effects,such as hydroxylation,dehalogenation,demethylation,decarboxylation and deamination,etc. on pharmaceutical activated compounds,which oxidize pharmacologically active compounds to become non-toxic and harmless substances. In this paper,a comprehensive discourse in the aspects of the mechanism of ultrasonic degradation of pharmacologically activated compounds,the main influencing factors,and the combination of ultrasonic and other water treatment technologies is presented. In addition,the problems to be solved and developing directions of ultrasonic technology in large-scale application in the future are pointed out.

Key words: ultrasound, ultrasonic degradation, pharmacologically active compounds

中图分类号:

X703

刘晨, 陈云嫩, 郭琳, 李畅. 超声技术在降解药物活性化合物中的应用[J]. 工业水处理, 2018, 38(9): 12-16.

Liu Chen, Chen Yunnen, Guo Lin, Li Chang. Application of ultrasonic technology to the degradation of pharmaceutically active compounds[J]. INDUSTRIAL WATER TREATMENT, 2018, 38(9): 12-16.

https://www.iwt.cn/CN/Y2018/V38/I9/12

参考文献

[1] 吕小明. 典型新兴环境污染物的研究进展[J]. 中国环境监测, 2012,28(4):118-123.
[2] Farre M L,Perez S,Kantiani L,et al. Fate and toxicity of emerging pollutants,their metabolites and transformation products in the aquatic environment[J]. Trends in Analytical Chemistry,2008,27(11):991-1007.
[3] 郑少奎,李晓锋. 城市污水处理厂出水中的药品和个人护理品[J]. 环境科学,2013,34(8):3316-3326.
[4] 安婧,周启星. 药品及个人护理用品(PPCPs)的污染来源、环境残留及生态毒性[J]. 生态学杂志,2009,28(9):1878-1890.
[5] Chowdhury P,Viraraghavan T. Sonochemical degradation of chlorinated organic compounds,phenolic compounds and organic dyes:A review[J]. Science of Total Environment,2009,407(8):2474-2492.
[6] 徐力克,邓慧萍,史俊. 超声波降解有机物机理及其应用研究[J]. 环境科学与技术,2010,33(12):416-500.
[7] 刘玥,彭赵旭,闫怡新. 水处理高级氧化技术及工程应用[M]. 郑州:郑州大学出版社,2014:174-187.
[8] Bhangu S K,Ashokkumar M. Theory of sonochemistry[J]. Topics in Current Chemistry,2016,374(4):1-28.
[9] 张光明. 水处理高级氧化技术[M]. 哈尔滨:哈尔滨工业大学出版社,2007:80-103.
[10] 刘春明,董秀芹,张敏华. 超临界水氧化技术处理工业废水的研究进展[J]. 化工进展,2011,30(8):1841-1848.
[11] Veriansyah B,Kim J D. Supercritical water oxidation for the destruction of toxic organic wastewaters:A review[J]. Journal of Environmental Sciences,2007,19(5):513-522.
[12] Nejumal K K,Manoj P R,Aravind U,et al. Sonochemical degradation of a pharmaceutical waste,atenolol,in aqueous medium[J]. Environmental Science and Pollution Research,2014,21(6):4297-4308.
[13] Rao Y F,Yang H S,Xue D,et al. Sonolytic and sonophotolytic degradation of carbamazepine:Kinetic and mechanisms[J]. Ultrasonics Sonochemistry,2016,32:371-379.
[14] Hung H M,Hoffmann M R. Kinetics and mechanism of the sonolytic degradation of chlorinated hydrocarbons:Frequency effects[J]. Journal of Physical Chemistry A,1999,103(15):2734-2739.
[15] Goel M,Hongqiang H,Mujumdar A S,et al. Sonochemical decomposition of volatile and non-volatile organic compounds:A comparative study[J]. Water Research,2004,38(19):4247-4261.
[16] Mason T J,Lorimer J P,Walton D J. Sonoelectrochemistry[J]. Ultrasonics,1990,28(5):333-337.
[17] Naddeo V,Meric S,Kassinos D,et al. Fate of pharmaceuticals in contaminated urban wastewater effluent under ultrasonic irradiation[J]. Water Research,2009,43(16):4019-4027.
[18] Guo W L,Wang H Z,Shi Y H,et al. Sonochemical degradation of the antibiotic cephalexin in aqueous solution[J]. Water Sa,2010, 36(5):651-654.
[19] 陈伟,范瑾初. 超声降解水体中有机污染物的效果及影响因素[J]. 给水排水,2000(5):19-21.
[20] Wang X,Wang Y,Li D. Degradation of tetracycline in water by ultrasonic irradiation[J]. Water Science and Technology,2013,67(4):715-721.
[21] 邱潇潇,丁旸,曹玉龙. 超声波技术在污水处理中的研究进展[J].科技创新导报,2008(13):103-105.
[22] 王宏青,聂长明,徐伟昌,等. 灭多威的超声降解研究[J]. 应用声学,2001,20(2):35-37.
[23] Wang Y,Zhang H,Chen L.Ultrasound enhanced catalytic ozonation of tetracycline in a rectangular air-lift reactor[J]. Catalysis Today, 2011,175(1):283-292.
[24] Guo W Q,Yin R L,Zhou X J,et al. Sulfamethoxazole degradation by ultrasound/ozone oxidation process in water:Kinetics,mechanisms, and pathways[J]. Ultrasonics Sonochemistry,2015,22(23):182-187.
[25] Schneider J,Matsuoka M,Takeuchi M,et al. Understanding TiO₂ photocatalysis:Mechanisms and materials[J]. Chemical Reviews, 2014,114(19):9919-9986.
[26] Zhou T,Wu X,Zhang Y,et al. Synergistic catalytic degradation of antibiotic sulfamethazine in a heterogeneous sonophotolytic goethite/oxalate Fenton-like system[J]. Applied Catalysis B:Environmental,2013,136/137(21):294-301.
[27] Zhou T,Wu X,Mao J,et al. Rapid degradation of sulfonamides in a novel heterogeneous sonophotochemical magnetite-catalyzed Fenton-like(US/UV/Fe₃O₄/oxalate) system[J]. Applied Catalysis B:Environmental,2014,160/161(1):325-334.
[28] Eskandarloo H,Badiei A,Behnajady M A,et al. Ultrasonic-assisted degradation of phenazopyridine with a combination of Sm-doped ZnO nanoparticles and inorganic oxidants[J]. Ultrasonics Sonochemistry,2016,28:169-177.
[29] Brillas E,Sires I,Oturan M A. Electro-Fenton process and related electrochemical technologies based on Fenton's reaction chemistry[J]. Chemical Reviews,2009,109(12):6570-6631.
[30] Thokchom B,Pandit A B,Qiu P,et al. A review on sonoelectrochem-ical technology as an upcoming alternative for pollutant degradation[J]. Ultrasonics Sonochemistry,2015,27:210-234.
[31] Finkbeiner P,Franke M,Anschuetz F,et al. Sonoelectrochemical degradation of the anti-inflammatory drug diclofenac in water[J]. Chemical Engineering Journal,2015,273:214-222.
[32] Thokchom B,Kim K,Park J,et al. Ultrasonically enhanced electrochemical oxidation of ibuprofen[J]. Ultrasonics Sonochemistry, 2015,22:429-436.

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