Research progress on treatment of antibiotic-containing wastewater by microalgae

doi:10.19965/j.cnki.iwt.2023-0622

Abstract

Abstract:

With the wide application of antibiotics, the treatment problem of wastewater containing antibiotics is already imminent. Microalgae technology has been proved to have the potential to degrade antibiotic pollutants, and has been widely studied by industry scholars. As mixotrophic organisms, microalgae can synthesize compounds such as sugars, proteins and lipids by absorbing CO₂and nutrients, which have been confirmed to have the potential to degrade pollutants. This paper summarizes the results of the traditional and new methods of microalgae and various methods. The biomass synthesis of treated microalgae, the mechanisms of antibiotic degradation were explored and the contributions of these mechanisms were compared. Finally, the shortage of microalgae treatment of antibiotic-containing wastewater is summarized and the following research direction should be clarified, in order to lay a foundation for the further large-scale development and resource utilization of microalgae treatment in the future.

Key words: microalgae, antibiotics, wastewater treatment, biomass, degradation mechanism

摘要：

随着抗生素的广泛应用，含抗生素类废水的处理问题已然迫在眉睫。微藻技术已被证实具有降解抗生素污染物的潜力，现已被行业学者广泛研究。微藻作为混合营养型生物，可以通过吸收CO₂和营养物质来合成糖类、蛋白质和脂质等化合物，现已被证实具有降解污染物的潜力。综述了利用微藻处理含抗生素废水的传统方法和新型方法、多种方法协同处理的效果及其优劣势。探讨了处理后微藻的生物质合成情况、抗生素的降解机制并比较了这些机制的贡献。最后总结了目前利用微藻处理含抗生素类废水的不足并且阐明了后续需重点关注的研究方向，以期为日后微藻处理抗生素进一步规模化发展和资源化利用打下基础。

关键词: 微藻, 抗生素, 废水处理, 生物质, 降解机制

CLC Number:

X703

Bo WANG, Lijie ZHANG, Junren CHEN, Zian REN, Yuejun QI. Research progress on treatment of antibiotic-containing wastewater by microalgae[J]. Industrial Water Treatment, 2024, 44(8): 44-52.

王渤, 张立杰, 陈俊任, 任子安, 齐悦君. 微藻处理含抗生素类废水研究进展[J]. 工业水处理, 2024, 44(8): 44-52.

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URL: https://www.iwt.cn/EN/10.19965/j.cnki.iwt.2023-0622

https://www.iwt.cn/EN/Y2024/V44/I8/44

Figures/Tables 2

References 57

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抗生素种类	抗生素质量浓度/（mg∙L^-1）	藻种	处理时间/h	培养条件	生物量/ （g∙L^-1）	油脂/ （mg∙L^-1）	去除率/ %	参考文献
头孢他啶	40	C. pyrenoidosa	6	BG11培养基	—	—	92.7	〔48〕
7-ACA	40	C. pyrenoidosa	6~24	BG11培养基	—	—	60.3~76.0	〔48〕
头孢拉定	10	C. pyrenoidosa	24~48	BG11培养基	—	—	69.7~89.9	〔20〕
头孢他啶	10	C. pyrenoidosa	24~48	BG11培养基	—	—	88.7~89.7
头孢氨苄	10	C. pyrenoidosa	24~48	BG11培养基	—	—	48.5~94.9
头孢克肟	10	C. pyrenoidosa	24	BG11培养基	—	—	99.9
头孢他啶	5	C. pyrenoidosa	24	BG11培养基	—	—	94.6
头孢他啶	50	C. pyrenoidosa	24	BG11培养基	—	—	91.2
头孢他啶	100	C. pyrenoidosa	24	BG11培养基	—	—	89.4
头孢他啶	150	C. pyrenoidosa	24	BG11培养基	—	—	84.5
头孢拉定	100	C. pyrenoidosa	48	与活性污泥协同处理	—	—	97.9
头孢拉定	50	C. pyrenoidosa	24~72	BG11+250 mg/L NaNO₃+50 mg/L K₂HPO₄	—	—	78.9~94.4	〔16〕
头孢拉定	50	M.aeruginosa	24~72	BG11+250mg/L NaNO₃+50 mg/L K₂HPO₄	—	—	64.2~91.3	〔16〕
7-ACA	53	Chlorella sp. Cha-01	24~48	BG11	0.6~2.7	—	55.1~90.4	〔49〕
7-ACA	53	Chlamydomonas sp. Tai-03	24~48	BG11	0.3~1.0	—	90.4~83.5
头孢拉定	50	C. pyrenoidosa	0~24	BG11	—	40.3~31.1	0~41.5
头孢拉定	50	M. aeruginosa	24	BG11	—	—	37.1
头孢拉定	50	C. pyrenoidosa+ M. aeruginosa	24	C. pyrenoidosa培养在M. aeruginosa 渗滤液中	—	—	75.5	〔17〕
头孢拉定	50	C. pyrenoidosa+ M. aeruginosa	24	双藻种等生物量混合培养	—	—	58.8
头孢拉定	50	C. pyrenoidosa+ M. aeruginosa	24	M. aeruginosa培养在C. pyrenoidosa 渗滤液中	—	—	12.8
诺氟沙星	50	C. pyrenoidosa	24	BG11	—	—	7.89
诺氟沙星	50	C. pyrenoidosa	24	C. pyrenoidosa处理6 h+ 活性污泥处理18 h	—	—	58.4
诺氟沙星	45	C. pyrenoidosa	30	活性污泥处理24 h+ C. pyrenoidosa处理6 h	—	—	51.4
头孢拉定	150	C. pyrenoidosa	24	BG11	—	—	17.6	〔24〕
头孢拉定	150	C. pyrenoidosa	24	BG11+ 365 nm紫外照射	—	—	77.9
阿莫西林	100	C. pyrenoidosa	48	BG11	—	—	97.4
阿莫西林	200	C. pyrenoidosa	48	BG11	—	—	95.1
阿莫西林	300	C. pyrenoidosa	48	BG11	—	—	94.7
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=4	—	—	99.8	〔25〕
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=7	—	—	98.9
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=10	—	—	97.4
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=20	—	—	96.9
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=4	—	—	95.5
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=7	—	—	94.8
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=10	—	—	94.2
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=20	—	—	93.9
左氧氟沙星	1	C. vulgaris		BG11培养基	—	—	11.7	〔26〕
左氧氟沙星	5	C. vulgaris	11 d	BG11培养基	—	—	8.6
左氧氟沙星	10	C. vulgaris		BG11培养基	—	—	6.1
左氧氟沙星	1 000	C. vulgaris	11 d	BG11+经过1 mg/L的左氧氟沙星驯化11 d	—	—	12.3
左氧氟沙星	1 000	C. vulgaris		BG11+经过50 mg/L的左氧氟沙星驯化11 d	—	—	15.3
左氧氟沙星	1 000	C. vulgaris	11 d	BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	27.8
左氧氟沙星	1	C. vulgaris		BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	27.8
左氧氟沙星	5	C. vulgaris	11 d	BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	12.9
左氧氟沙星	10	C. vulgaris		BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	10.3
左氧氟沙星	1 000	C. vulgaris	11 d	BG11+1%NaCl	—	—	91.5
左氧氟沙星	1 000	C. vulgaris		BG11+经过200 mg/L的左氧氟沙星驯化11 d+1% NaCl	—	—	90.2
无	0	集胞藻	18 d	BG11培养基	0.018	0.002（14.7%）	—	〔35〕
环丙沙星	0.000 1	集胞藻	18 d	BG11培养基	0.025	0.005 （20.9%）	—
阿莫西林	0.000 1	集胞藻	18 d	BG11培养基	0.029	0.006 （20.5%）	—
磺胺甲唑	0.000 1	集胞藻	18 d	BG11培养基	0.033	0.006 （19.1%）	—
四环素	0.000 1	集胞藻	18 d	BG11培养基	0.032	0.005 （16.9%）	—
螺旋霉素	0.000 1	集胞藻	18 d	BG11培养基	0.033	0.005 （15.3%）	—
庆大霉素	15	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	10.4	1.3	—	〔36〕
庆大霉素	25	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	8.4	1.5	—
四环素	15	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	7.8	2.1	—
卡那霉素	10	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	10.9	1.3	—
卡那霉素	20	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	8.5	1.4	—
链霉素	25	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	6.4	1.9	—
新霉素	20	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	8.8	1.4	—
巴龙霉素	5	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	9.2	1.9	—
磺胺甲唑	0.1	Chlorella sorokiniana	10 d	BG11培养基	—	—	60.4	〔57〕
磺胺甲唑	5	Chlorella sorokiniana	10 d	BG11培养基	—	—	86.6	〔57〕

抗生素种类	抗生素质量浓度/（mg∙L^-1）	藻种	处理时间/h	培养条件	生物量/ （g∙L^-1）	油脂/ （mg∙L^-1）	去除率/ %	参考文献
头孢他啶	40	C. pyrenoidosa	6	BG11培养基	—	—	92.7	〔48〕
7-ACA	40	C. pyrenoidosa	6~24	BG11培养基	—	—	60.3~76.0	〔48〕
头孢拉定	10	C. pyrenoidosa	24~48	BG11培养基	—	—	69.7~89.9	〔20〕
头孢他啶	10	C. pyrenoidosa	24~48	BG11培养基	—	—	88.7~89.7
头孢氨苄	10	C. pyrenoidosa	24~48	BG11培养基	—	—	48.5~94.9
头孢克肟	10	C. pyrenoidosa	24	BG11培养基	—	—	99.9
头孢他啶	5	C. pyrenoidosa	24	BG11培养基	—	—	94.6
头孢他啶	50	C. pyrenoidosa	24	BG11培养基	—	—	91.2
头孢他啶	100	C. pyrenoidosa	24	BG11培养基	—	—	89.4
头孢他啶	150	C. pyrenoidosa	24	BG11培养基	—	—	84.5
头孢拉定	100	C. pyrenoidosa	48	与活性污泥协同处理	—	—	97.9
头孢拉定	50	C. pyrenoidosa	24~72	BG11+250 mg/L NaNO₃+50 mg/L K₂HPO₄	—	—	78.9~94.4	〔16〕
头孢拉定	50	M.aeruginosa	24~72	BG11+250mg/L NaNO₃+50 mg/L K₂HPO₄	—	—	64.2~91.3	〔16〕
7-ACA	53	Chlorella sp. Cha-01	24~48	BG11	0.6~2.7	—	55.1~90.4	〔49〕
7-ACA	53	Chlamydomonas sp. Tai-03	24~48	BG11	0.3~1.0	—	90.4~83.5
头孢拉定	50	C. pyrenoidosa	0~24	BG11	—	40.3~31.1	0~41.5
头孢拉定	50	M. aeruginosa	24	BG11	—	—	37.1
头孢拉定	50	C. pyrenoidosa+ M. aeruginosa	24	C. pyrenoidosa培养在M. aeruginosa 渗滤液中	—	—	75.5	〔17〕
头孢拉定	50	C. pyrenoidosa+ M. aeruginosa	24	双藻种等生物量混合培养	—	—	58.8
头孢拉定	50	C. pyrenoidosa+ M. aeruginosa	24	M. aeruginosa培养在C. pyrenoidosa 渗滤液中	—	—	12.8
诺氟沙星	50	C. pyrenoidosa	24	BG11	—	—	7.89
诺氟沙星	50	C. pyrenoidosa	24	C. pyrenoidosa处理6 h+ 活性污泥处理18 h	—	—	58.4
诺氟沙星	45	C. pyrenoidosa	30	活性污泥处理24 h+ C. pyrenoidosa处理6 h	—	—	51.4
头孢拉定	150	C. pyrenoidosa	24	BG11	—	—	17.6	〔24〕
头孢拉定	150	C. pyrenoidosa	24	BG11+ 365 nm紫外照射	—	—	77.9
阿莫西林	100	C. pyrenoidosa	48	BG11	—	—	97.4
阿莫西林	200	C. pyrenoidosa	48	BG11	—	—	95.1
阿莫西林	300	C. pyrenoidosa	48	BG11	—	—	94.7
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=4	—	—	99.8	〔25〕
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=7	—	—	98.9
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=10	—	—	97.4
阿莫西林	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=20	—	—	96.9
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=4	—	—	95.5
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=7	—	—	94.8
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=10	—	—	94.2
头孢拉定	1 000	C. pyrenoidosa	48	联合Fenton工艺处理 n（H₂O₂）/n（Fe²⁺）=20	—	—	93.9
左氧氟沙星	1	C. vulgaris		BG11培养基	—	—	11.7	〔26〕
左氧氟沙星	5	C. vulgaris	11 d	BG11培养基	—	—	8.6
左氧氟沙星	10	C. vulgaris		BG11培养基	—	—	6.1
左氧氟沙星	1 000	C. vulgaris	11 d	BG11+经过1 mg/L的左氧氟沙星驯化11 d	—	—	12.3
左氧氟沙星	1 000	C. vulgaris		BG11+经过50 mg/L的左氧氟沙星驯化11 d	—	—	15.3
左氧氟沙星	1 000	C. vulgaris	11 d	BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	27.8
左氧氟沙星	1	C. vulgaris		BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	27.8
左氧氟沙星	5	C. vulgaris	11 d	BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	12.9
左氧氟沙星	10	C. vulgaris		BG11+经过200 mg/L的左氧氟沙星驯化11 d	—	—	10.3
左氧氟沙星	1 000	C. vulgaris	11 d	BG11+1%NaCl	—	—	91.5
左氧氟沙星	1 000	C. vulgaris		BG11+经过200 mg/L的左氧氟沙星驯化11 d+1% NaCl	—	—	90.2
无	0	集胞藻	18 d	BG11培养基	0.018	0.002（14.7%）	—	〔35〕
环丙沙星	0.000 1	集胞藻	18 d	BG11培养基	0.025	0.005 （20.9%）	—
阿莫西林	0.000 1	集胞藻	18 d	BG11培养基	0.029	0.006 （20.5%）	—
磺胺甲唑	0.000 1	集胞藻	18 d	BG11培养基	0.033	0.006 （19.1%）	—
四环素	0.000 1	集胞藻	18 d	BG11培养基	0.032	0.005 （16.9%）	—
螺旋霉素	0.000 1	集胞藻	18 d	BG11培养基	0.033	0.005 （15.3%）	—
庆大霉素	15	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	10.4	1.3	—	〔36〕
庆大霉素	25	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	8.4	1.5	—
四环素	15	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	7.8	2.1	—
卡那霉素	10	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	10.9	1.3	—
卡那霉素	20	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	8.5	1.4	—
链霉素	25	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	6.4	1.9	—
新霉素	20	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	8.8	1.4	—
巴龙霉素	5	Graesiella emersonii Cd13	5 d	BG11+15 g/L葡萄糖	9.2	1.9	—
磺胺甲唑	0.1	Chlorella sorokiniana	10 d	BG11培养基	—	—	60.4	〔57〕
磺胺甲唑	5	Chlorella sorokiniana	10 d	BG11培养基	—	—	86.6	〔57〕

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